The comedian, who shares 12 children with six women appeared on Wild ‘N Out, which aired on May 25, where he made the quip about the pro wrestler.
The actor and TV host was performing a spoof of the Fresh Prince of Bel-Air theme song when he made the joke in front of Bianca and her shocked husband Montez Ford.
Nick rapped: ‘There’s a couple of guys who were up to no good, they starting making trouble in my neighbourhood. I get in one little fight, my mum got scared…’
He then proceeded to grind up against Bianca as he continued: ‘Because I wanted to impregnate Bianca Belair.’
Belair and Ford have been married since 2018.
While Bianca and Montez laughed off the dig, viewers were left shocked, tweeting: ‘Nick Cannon is pure garbage.
Another tweet reads: ‘I know my ears deceive me ain’t no way nick cannon said he wanted to get Bianca pregnant @BiancaBelairWWE that’s a threat girl contact the authorities.’
‘Nick cannon saying he wanted to impregnate Bianca is weird on like every level?? Like what even possesses your brain to even wanna say something like that’, another user commented.
The dig comes a month after Nick made similar joke that he wanted Taylor Swift to be the mother of his 13th child.
Nick – who shares 12 children with six different women – was on The Howard Stern Show last month, when he was asked which celebrities he would father a child with.